Chromogranin A and pancreastatin
نویسندگان
چکیده
منابع مشابه
Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A.
Using an antiserum raised against a synthetic C-terminal peptide of porcine pancreastatin, we detected pancreastatin-like immunoreactivity (PLI) in human pancreatic islets, adrenal medulla, and endocrine tumors. From a carcinoid liver metastasis, human PLI was extracted and purified by HPLC. Two C-terminally amidated peptides were isolated and characterized by sequence analysis. The first pepti...
متن کاملDiscovery of a Novel Target for the Dysglycemic Chromogranin A Fragment Pancreastatin: Interaction with the Chaperone GRP78 to Influence Metabolism
RATIONALE The chromogranin A-derived peptide pancreastatin (PST) is a dysglycemic, counter-regulatory peptide for insulin action, especially in liver. Although previous evidence for a PST binding protein has been reported, such a receptor has not been identified or sequenced. METHODS AND RESULTS We used ligand affinity to purify the PST target, with biotinylated human PST (hCHGA273-301-amide)...
متن کامل[Chromogranin A and neuroendocrine tumors].
Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly differentiated tumors, it is the best tumor marker ...
متن کاملChromogranin A and Neuroendocrine Tumors
A neuroendocrine tumor is suspected when classical clinical symptoms occur but the large majority of NETs does not show any specific symptomatology (Oberg et al., 1999). Accordingly, the biochemical diagnosis is of great value, with the validation of radioimmunoenzymatic assays for various circulating peptide hormones in the last decade, clinical awareness and ability to diagnose NET is increas...
متن کاملChromogranin A (CgA) References
"There appears to be a direct correlation between tumor burden and serum CgA levels. Rising serum levels of CgA can predeed radiographic evidence of recurrence. . . . .Using serum CgA level above 30 U/ml, one is able to discriminate between disease free patients and those with recurrent metastatic disease with a sensitivity of 92% and specificity of 96%. This is superior to measuring urinary 5-...
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ژورنال
عنوان ژورنال: Nature
سال: 1987
ISSN: 0028-0836,1476-4687
DOI: 10.1038/325305b0